Continuous Flow Reactors for Gas/Liquid Chemical Processes
Conference Recording Apr 07, 2013
About the SpeakerGraham Sandford obtained his Ph.D. in Organofluorine Chemistry at Durham, under the supervision of Prof. R.D. Chambers. After a period as a postdoctoral research fellow in the laboratories of Prof. George Olah (USC), he transferred back to Durham. Following post-doctoral support from F2 Chemicals Ltd. (BNFL), he was awarded a Royal Society University Research Fellowship, which began in October 1996. He was appointed to a Lectureship in the Department of Chemistry at Durham in March 2001, Senior Lecturer in October 2004 and promoted to Chair beginning in October 2008. He has published over 130 research papers, review articles and patent applications, mainly in the field of organofluorine chemistry.
The use of continuous flow reactors for gas/liquid chemical reactions remains relatively undeveloped even though application of such devices for reactions involving highly reactive gases may, potentially, be highly beneficial. Our long term interest in the synthesis of molecules bearing fluorine atom substituents by selective transformation of carbon-hydrogen bonds to carbon-fluorine bonds using highly reactive elemental fluorine, prompted us to develop flow reactor systems for the purpose of increasing selectivity, controllability and safety of direct fluorination processes. The development and use of practical, easily maintained, economic and simple multi-channel thin film gas/liquid flow reactors that may be fabricated using standard workshop techniques will be described. Direct fluorination of 1,3-dicarbonyl systems on a practical scale (e.g. 100 g per 24 hour period in a 9-channel device) demonstrates the applicability of flow devices for industry. Recent use of the HOF.MeCN complex, formed by reaction of fluorine with water in acetonitrile, for various oxidation processes will also be presented.