Development of Biostabilization Methods in all Ambient Workflow for Point-of-Care Molecular Diagnostics MDx
Conference Recording Dec 01, 2013
About the SpeakerRolf Müller, Ph.D. is co-founder of Biomatrica and serves as its Chief Scientific Officer. He oversees the patent portfolio, laboratory operations, new product development and strategic alliances. Dr. Müller has more than 10 years of experience in starting biotechnology companies and is an expert in high throughput genomics and proteomics technologies. He was most recently a Visiting Scientist and Director, Assay Development and High Throughput Screening for the HIV Core Program Project Grant at the Scripps Research Institute, San Diego, CA. Prior to his position at Scripps, he served as Director of Molecular Biology at HK Pharmaceuticals, where he assisted in establishing the company and conceptualized the drug discovery process. Before HK, Rolf was the Director of the Total Gene Expression Analysis Services Department at Digital Gene Technologies and was responsible for scientific direction, including industrial scale gene discovery, database mining and bioinformatics integration. He also served as a scientist at the Salk Institute studying cell signaling and viral based gene therapy approaches.Abstract There is an increasing need for the development of technologies for handling human specimens in an all ambient workflow at point-of-care, laboratory and field settings without sacrificing the quality of molecular analytes contained in patient samples. Biomatrica has developed sample biostabilization technology that eliminates the need for cold chain transport and storage of specimens, resulting in significant cost savings for the diagnostic laboratory workflow. Data will be presented to demonstrate that such biostabilized nucleic acid samples retain near-native quality and quantity compared to fresh samples and can also be used for molecular diagnostics based on comprehensive genomic data generated by next-gen sequencing platforms. Biomatrica’s biostabilization based complete ambient diagnostic workflow holds great promise for molecular diagnostic applications in a point of care setting.