Improved Oral Delivery of Antiretroviral Drugs Via A Novel Synthesis of Solid Drug Nanoparticle Formulations
Conference Recording May 27, 2014
About the Speaker
Andrew Owen, Ph.D. FSB holds a personal Chair in the Department of Molecular and Clinical Pharmacology at the University of Liverpool, UK. He is also affiliated to the MRC Centre for Drug Safety Science and the Wolfson Centre for Personalised Medicine. He is Chair of the British Society for Nanomedicine, a fellow of the Society of Biology and a member of the Nanomed Focus Group Steering Committee and British Pharmacological Society. Professor Owen is also a member of the editorial board for Nanomedicine: nanotechnology, biology and medicine.Abstract
An overview of data describing translocation of nanomaterials following pulmonary, oral and intravenous, delivery and then relating this to local and distal effects (e.g. in the liver) including oxidative stress and inflammatory gene changes. There is an urgent need for better in vitro alternatives for nanomaterial toxicity testing. This study compares local and distal responses with in vitro responses to nanomaterials and identifies scenarios that work, that don’t work and makes suggested changes for the future.