Multiplexed Measurement of Disease Biomarkers by Mass Spectometry (MRM) for Predictive and Prognostic Purposes
Conference Recording Nov 17, 2013
About the Speaker
Steve is currently Professor of Proteomics and a Director of the Proteome Research Centre in the UCD Conway Institute of Biomolecular and Biomedical Research at University College Dublin. Steve graduated from Imperial College of Science and Technology (University of London) with a joint honours degree in Chemistry and Biochemistry before completing a PhD in Biochemistry at the University of Cambridge. During his PhD he was awarded an Elmore Medical Research Fellowship.
The application of a range of proteomics strategies has resulted in the discovery of very large numbers of potential new protein biomarkers but few have reached clinical utility for (a) understanding the molecular mechanisms of disease pathogenesis, (b) identifying new therapeutic targets, or (c) implementing biomarker based personalised treatment. Some of the challenges faced in the protein biomarker development process and potential solutions will be described from our recent studies on prostate cancer and psoriatic arthritis. In these on-going collaborative projects we are developing a ‘clinical question focused’ pipeline for candidate protein biomarker assembly and validation of 'protein biomarker signatures' by multiple reaction monitoring (MRM). The potential of this approach for the delivery of more personalised patient treatment will be discussed.