Pathology is Phenotyping. What Do Pathologists Do? How Do they Do It?
Conference Recording May 20, 2014
About the SpeakerDean A. Troyer, M.D., Managing Partner, is a diplomate of the College of American Pathologists in Anatomic and Clinical Pathology. During his approximately 20 year academic career he has published extensively, served on national committees for review of grants, and is currently a co-Principal Investigator of the Early Detection Research Network, a national consortium funded by the National Cancer Institute. He is an academically based pathologist with extensive experience in translational research. His specific research interests are cancers of the prostate, kidney, bladder and medical diseases of the kidney. He is broadly experienced in surgical pathology, tissue banking, data base utility, and management of histology laboratories.
AbstractMicroscopic examination remains the gold standard for classification and staging of cancer and other diseases. Any diagnostic test that relies on tissue must fit into this work flow. Histology is the processing of tissue biopsies for microscopic evaluation. It is crucial to understand how a diagnostic test fits into the landscape of pathology and clinical medicine. This presentation will include a practical overview of diagnostic pathology as it relates to existing diagnostic tools such as immunohistochemistry and fluorescence in situ hybridization. Newer diagnostics must find their place in this workflow. Some rules of the road about diagnostic markers/tests: they should change clinical practice; tissue houses the most concentrated and unaltered forms of tumor markers; pricing is relevant; pathologists are cost effective – your marker should pick up where they leave off; multiplexing is preferable; they must fit into the existing work flow of histopathology.