Single Cell Analysis of Senescent Cells
Conference Recording Nov 11, 2013
About the SpeakerJames M. Flynn has been a postdoctoral fellow at the Buck Institute for Research on Aging (Novato, CA) since late 2008 in the laboratory of Dr. Simon Melov. Dr. Flynn received his Ph.D. from the department of Cell Biology and Genetics at the University of North Texas Health Science Center in 2008. His current research focuses on mouse models of premature aging and mitochondrial oxidative stress. This line of research has lead to the use of single cell microarray and nanofluidic qPCR to examine the transcriptional changes in age-related disease.
AbstractAs we age, our cells undergo a process where they enter a senescent state as a potent tumor suppression mechanism, but this cellular change may also contribute to the aging pathology seen within tissues including inflammation and bioenergetic compromise. In this talk the use of single cell analysis is used to dissect the cellular transition from a quiescent to senescent state.