Unravelling Pathogen Virulence Strategies through the Application of Transcriptomics and Real-time Imaging
Conference Recording Mar 01, 2014
About the SpeakerMurray Grant graduate with a PhD in Biochemistry from Otago University. He studied nitrogen assimilation with the DSIR in New Zealand. He was recipient of the first Royal Society Endeavour Fellowship in 1990, studying at the John Innes and in 1993 moved into molecular plant pathology as a Human Capital and Mobility Fellow with Jeff Dangl in Koln. He continued in this field, first at Leicester University in 1996, moving to Wye College in 1998 and on to a Chair at Exeter University in 2006.
AbstractUnderstanding plant pathogen virulence mechanisms provides the opportunity to deploy targeted intervention strategies. Successful pathogens deploy a collection of “effector” molecules to attenuate plant defense surveillance systems. Virulent Pseudomonas syringae establishes disease in Arabidopsis thaliana through the collective activities of a suite of ~ 30 effector proteins delivered into the plant cell. An emerging paradigm is that effectors hijack plant hormonal signalling to promote disease. Using a combination of time resolved transcriptomics, reverse genetics and real time imaging combined with network inference we are beginning to understand how P. syringae modulates jasmonate and ABA signaling. Surprisingly these studies reveal that bacterial effectors rapidly target the chloroplast, the site of hormone biosynthesis, as a key virulence strategy.
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