Dr Gareth Guenigault
Lead Scientist CRO Services, CN Bio
Dr Gareth Guenigault is a Lead Scientist at CN Bio, an Organ-on-a-Chip company based in Cambridge UK. Gareth is responsible for the Contract Research Services arm of CN Bio’s business, where he oversees the design and implementation of customer studies to test novel therapeutic candidates using the company's advanced in vitro 3D models. Gareth and his team have played an instrumental role in the development of CN Bio’s human NASH model. They have created a set of highly customizable, industry-proven, set of assays that replicate the key elements of human non-alcoholic fatty liver disease and NASH. Before joining CN Bio, Gareth completed a PhD at Cardiff University before accepting a Post-Doc position at Cambridge University focused on the fields of Virology and Immunology.
The Human Touch: How Liver-on-a-Chip Addresses the Unmet Needs of Liver Disease Research
• Liver disease progresses from a dysregulation of metabolism
• Lipid metabolism differs between mice and men and the impact this has on drug development
• Primary human NASH models can evaluate drugs that target metabolism
• NASH models allow the quantitation of lipid droplets, metabolism and fibrosis