Dr. Johanna Tüshaus

Postdoctoral Researcher - Technical University Munich

Johanna obtained her Master’s degree from TU Darmstadt in biochemistry. She followed this with a PhD focused on proteomic method development and Alzheimer´s disease in the laboratory of Stefan Lichtenthaler at DZNE, Munich and Carl Blobel at Weill Cornell Medicine, New York City. Her PhD work was honored with the PhD prize of the DGPF (Deutsche Gesellschaft für Proteomforschung). Now, she is a postdoctoral researcher at the laboratory of Bernhard Kuster at TU Munich in the framework of the CLINSPECT-M consortium.

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Published Content

Total: 1

Webinar

Hidden Traces – Using Chimeric Spectra To Boost Protein Identification Rates

The field of mass spectrometry has advanced tremendously over the last decade on both the hardware as well as the software side. Nevertheless, we still do not use the full capacity of the acquired proteomic data and several layers of information get lost in typical label-free quantification data-dependent acquisition proteomic datasets. A major source of this information loss is the presence of chimeric spectra, which contain fragment ions from multiple peptides, and the inability to fully interpret them.

In this webinar, we explore how the CHIMERYS intelligent search algorithm gives us a handle to elucidate the hidden traces within chimeric spectra. We’ll also discuss how CHIMERYS increases instrument efficiency and protein identification rates through deconvolution of chimeric spectra, enabling new data acquisition strategies with wide-window acquisition.