Dr Tomasz Kostrzewski
Director of Biology, CN BIO Innovations
Towards a Body-on-a-Chip: The Value of Multi-Organ MPS for Human-Relevant Drug Assessment
Microphysiological Systems (MPS), also known as organ-on-a-chip, generate human-relevant 3D cell culture models whose phenotypes and functions mimic individual in vivo organs. When therapeutics are added, these models can generate results that translate into clinical outcomes more reliably than standard in vitro techniques.
Testing on Humans: How To Predict Hepatotoxicity and Drug Clearance Ahead of Clinical Trials Using Liver-on-a-Chip
Current in vitro approaches for investigational toxicology, drug metabolism (DMPK) and safety are limited and are not fully representative of human response; therefore, drugs showing acceptable preclinical toxicity often fail in human clinical trials, and accurately predicting human drug exposure for new compounds is challenging and costly.