Dr. Valerie Collins

Applications Manager
RedShiftBio

Valerie joined RedShiftBio in 2018 and her experience with Microfluidic Modulation Spectroscopy began prior to that, as the first external beta tester of the company’s original AQS3pro system. Valerie possesses a wealth of biophysical characterization experience and a research background in structural and spectroscopic characterization of proteins and peptides, focusing on amyloidosis. Valerie leads RedShiftBio’s internal and external field applications team and oversees all proof-of-concept studies worldwide.

Novel Protein Characterization for Biopharma Development

Protein stability is one of the most important critical quality attributes for a new biological drug. Unstable or misfolded proteins are prone to aggregation and precipitation, which can lead to lower activity as well as increased immunogenicity. There has been a long-standing interest in renaturing unfolded, misfolded or precipitated proteins.

In this webinar, our expert speakers will demonstrate how thermal and pressure stress changed the structure and melting point of two model proteins and resulted in the discovery of different structural rearrangements.

They will then discuss a novel method for solubilizing and refolding proteins using hydrostatic pressure to generate proteins whose structure matches that of the native protein, as confirmed by microfluidic modulation spectroscopy.