Michiel Fokkelman, PhD profile page

Dr. Michiel Fokkelman (Head of High Throughput Screening, Crown Bioscience Netherlands) completed his PhD in tumor cell biology at Leiden University, in which he applied lab automation and high content imaging for multiple screening projects. He then joined Charles River Laboratories where he worked as a scientist in Early Discovery. His research focused on drug discovery in a broad range of therapeutic areas and assay modalities, applying different detection technologies for HTS and profiling projects in both small molecule and large molecule domain. In 2021, he joined CBNL as Head of High Throughput Screening to expand the screening capacity & capabilities and establish a team in HTS. For this symposium, we will present how we used lab automation to establish a versatile and automated platform for screening in 3D assays using high content imaging. The platform is compatible with cell lines, organoids, and patient tissues, and provides reproducible and highly consistent results.