Birgit Schilling, PhD profile page

Director of the Mass Spectrometry Technology Center Buck Institute

Dr. Schilling is an associate professor and the director of the Mass Spectrometry Core at the Buck Institute for Research on Aging in California. She also holds the position of adjunct professor at the University of Southern California (USC). The Schilling lab develops and implements advanced innovative protein analytical technologies (including quantitative proteomics, posttranslational modifications, protein dynamics and biomarker discovery) to advance basic biology and biomedical research related to aging research. Her ongoing research projects include the investigation of protein phosphorylation, acylation and other posttranslational modifications, as well as differential expression of proteins during disease and aging processes.

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Published Content

Total: 1

Webinar

Challenges and Opportunities to Quantify Post-translational Modifications using Novel Proteomic Workflows and Approaches

On-Demand

We have been using fast scanning TripleTOF systems to analyze a variety of post-translational modifications (PTMs) using both data-independent acquisitions (DIA) and more recently multiple reaction monitoring-high resolution (MRM-HR) to identify, characterize and quantify PTM-containing peptides in a high-throughput format. While rich information has been obtained using traditional CID fragmentation approaches, many of the modifications we study are highly labile and difficult to characterize.