Prof. Dr. Nicola Zamboni

Adjunt Professor - ETH Zürich

Nicola Zamboni is an Adjunct Professor at ETH Zurich, Institute of Molecular Systems Biology. He earned his PhD in metabolic engineering at ETH Zurich (2003), and did a postdoctoral at the Genome Technology Center, Stanford University. In 2005 he back to Zurich to establish a lab dedicated to investigating metabolic function and regulation. The lab pursues a data-driven approach that builds on mass spectrometry, e.g. metabolomics and tracer studies with isotopes. Measurements are enriched with a multitude of computational developments for data analysis, integration, and interpretation.

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Published Content

Total: 1

Webinar

In-Depth Analysis of Lipids by Electron Activated Dissociation

Analyzing lipids can be a challenge but combining tandem mass spectra obtained from electron-activated dissociation (EAD) can make the process easier. In fact, over 1000 lipids can be analyzed by ballistic data-dependent acquisition liquid chromatography-mass spectrometry. This methodology produces a large number of high-quality EAD fragmented spectra, making annotation the limiting factor, but combinatorial fragmenters can be used to effectively solve this challenge.

In this webinar, we demonstrate how the ZenoTOF 7600 system can be used in a workflow for the routine analysis of lipids that enables the resolution of sn-isomerism and double bond positions from high-throughput EAD mass spectrometry data.