Dr. Yexuan Deng
Postdoctoral Fellow, Walter and Eliza Hall Institute of Medical Research
Yexuan Deng is a postdoctoral fellow in the Herold laboratory, Blood Cells and Blood Cancer division at WEHI. She was working as a visiting PhD candidate at WEHI and obtained her PhD from Nanjing University in China. Her work utilizes multiple CRISPR/Cas9 genome editing systems to achieve depletion or activation of specific genes in eukaryotic cells, which has been published in Immunity, Nature Communications, etc. Yexuan characterised the CRISPR activation mouse model (referred as dCas9a-SAM), which showed high efficiency in activating gene expression in the haematopoietic system. She used this system to develop a mouse model of double hit lymphoma by inducing pro-survival protein BCL-2 expression in Eμ-Myc transgenic, dCas9a-SAM knock-in haematopoietic stem and progenitor cells.