Investigating Craniofacial Development in Zebrafish

Using CRISPR genome editing in zebrafish, scientists with the Fralin Biomedical Research Institute at VTC linked an undiagnosed human disease with a rare genetic mutation that causes craniofacial abnormalities. The mutant zebrafish larva exhibited a striking increase in type II collagen, shown stained green in this underside view of lower jaw structures. Blue stain shows cell nuclei.