Automating ELISA-based Assays to Assess the Purity of Therapeutic Viral Vectors

Analytical Methods in Gene Therapy - Case Study with AGC Biologics Milan
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More about Analytical Methods in Gene Therapy

What's in the Case Study?

 In this Case Study, the Analytical Development group at AGC Biologics Milan, describes the automation of two ELISA-based workflows to assess lentiviral vector purity, using a Hamilton Microlab® STARlet liquid handler integrated with a plate washer, a plate spectrometer, and two plate incubators.

Highlights of this Case Study

  • Overview of the analytical methods automated by AGC Biologics Milan on Hamilton liquid Handlers
  • Detailed description of two ELISA-based automated workflows to assess the purity of the lentiviral vectors: residual benzonase and residual Host-Cell Proteins (HCP)
  • Advantages of the Hamilton VENUS Scheduler to plan and execute parallel assays using the same sample aliquot

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Hamilton Company

Hamilton Company specializes in the development, manufacturing and customization of precision measurement devices, automated liquid handling workstations, and sample management systems.

Hamilton Robotics

Hamilton Robotics provides solutions for fully automated workflows. Our automated liquid handler workstations provide consistent results for assays, ranging from low-throughput pipetting protocols to high-throughput systems with integrated sample storage.
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