DLS is a highly sensitive tool for measuring the hydrodynamic size of proteins in solution and can quantify changes in size or aggregation in response to a thermal ramp. Monitoring thermal stability of a protein by DLS is one way a multi-modal instrument like Uncle can collect several different pieces of stability data in a single experiment.
In this application note, you will discover:
How size and aggregation respond to thermal ramps and formulation changes
The advantages of using two kinds of light scattering as detection methods
How to inform your biologic formulations with these methods
