p-toluenesulfonic acid is frequently used in the manufacturing process as a counterion to salt formation. p-toluenesulfonates may be formed when the acid reacts with methanol, ethanol, or propanol used in the reaction pathway.
As these compounds are carcinogenic; therefore, they need to be accurately monitored and quantified during both the process and in the final control of the drug substance.
Download this application note to discover why HPLC-UV is the preferred analytical method and how it can be used to provide:
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