3D human primary human hepatocyte (PHH) liver spheroids are emerging as more physiologically and pathologically relevant preclinical human liver models for drug safety assessment and liver disease modeling. Recently, the advantages of PHH liver spheroids use in liver toxicity tests over the traditional 2D monolayer culture of PHHs has been demonstrated by many scientists.
Download this app note to discover a method that can:
- Be reproduced robustly and consistently for immediate end-user applications
- Easily produce sufficient materials such as total RNA for molecular analysis
- Be adapted for studying drug-induced liver toxicity
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