Controlling cell migration

Latest research

1. 1. Cell Biology
   2. Neuroscience

   KIS counteracts PTBP2 and regulates alternative exon usage in neurons

   Marcos Moreno-Aguilera, Alba M Neher ... Carme Gallego

   KIS, a kinase upregulated in the developmental brain, phosphorylates the PTBP2 splicing complex and modulates alternative exon usage for proper synaptic spine emergence and maturation.
2. 1. Cell Biology
   2. Neuroscience

   Unraveling the link between Neuropathy Target Esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier

   Mariana I Tsap, Andriy S Yatsenko ... Halyna R Shcherbata
3. 1. Neuroscience

   Chronic intermittent hypoxia reveals role of the Postinspiratory Complex in the mediation of normal swallow production

   Alyssa D Huff, Marlusa Karlen-Amarante ... Jan-Marino Ramirez

   Glutamatergic–cholinergic neurons in the postinspiratory complex are critical for swallow motor patterning and the coordination of swallow and breathing, which is disrupted by chronic intermittent hypoxia, a condition seen in many disorders associated with dysphagia and aspiration pneumonia.
4. 1. Neuroscience

   Unifying network model links recency and central tendency biases in working memory

   Vezha Boboeva, Alberto Pezzotta ... Athena Akrami

   Seemingly disparate working memory biases, including short-term serial and contraction biases, may arise from a common mechanism via the interaction of multiple networks, each operating over a distinct timescale.
5. 1. Genetics and Genomics

   Elimination of subtelomeric repeat sequences exerts little effect on telomere essential functions in Saccharomyces cerevisiae

   Can Hu, Xue-Ting Zhu ... Jin-Qiu Zhou

   Subtelomeric sequences in the yeast S. cerevisiae are dispensable for either cell proliferation or homologous recombination-mediated telomere maintenance in telomerase-null cells, suggesting that these sequences represent remnants of genome evolution.
6. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association

   Marcel Proske, Robert Janowski ... Dierk Niessing

   Structural promiscuity in PURA protein, induced by patient mutations, impacts nucleic acid binding, unwinding, and subcellular localization, indicating why so many patients display the full disease spectrum of PURA syndrome.
7. 1. Chromosomes and Gene Expression
   2. Immunology and Inflammation

   Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function

   Rajan M Thomas, Matthew C Pahl ... Andrew D Wells

   Foxp3 and Ikaros, two transcription factors genetically linked to autoimmune disease in humans, cooperate to establish the epigenomic and transcriptomic landscape of regulatory T cells.
8. 1. Neuroscience

   Octopamine integrates the status of internal energy supply into the formation of food-related memories

   Michael Berger, Michèle Fraatz ... Henrike Scholz

   Intense starvation with high internal energy levels results in remarkably stable food-related memories that persist beyond actual food intake and are associated with overeating.
9. 1. Microbiology and Infectious Disease
   2. Structural Biology and Molecular Biophysics

   Molecular mechanism of complement inhibition by the trypanosome receptor ISG65

   Alexander D Cook, Mark Carrington, Matthew K Higgins

   A structure derived from cryogenic electron microscopy shows how ISG65, an African trypanosome receptor that aids virulence, binds C3b and suggests mechanisms through which ISG65 might aid complement resistance.
10. 1. Structural Biology and Molecular Biophysics

    Dependence of nucleosome mechanical stability on DNA mismatches

    Thuy TM Ngo, Bailey Liu ... Taekjip Ha

    The mechanical stability of a nucleosome is enhanced upon the introduction of a single base pair mismatch that makes DNA more bendable, with implications on mismatch repair in vivo.