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FEATURED HOW TO GUIDES

 

Latest How To Guides

Preparing Perfect Non-Covalent Protein Complexes for Analysis by Mass Spectrometry: 12 Key Thoughts to Keep in Mind
Preparing Perfect Non-Covalent Protein Complexes for Analysis by Mass Spectrometry: 12 Key Thoughts to Keep in Mind
How To Guide

Preparing, purifying, analysing and identifying the constituent components of non-covalently-interacting protein complexes by mass spectrometry has become significantly simpler and easier over the last two decades. However there are still many points that are easily overlooked in the successful preparation and analysis of these complexes.

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Top Tips for RNA Extraction from Mouse Brain Tissue
Top Tips for RNA Extraction from Mouse Brain Tissue
How To Guide

Ribonucleic Acid (RNA) is essential for genetic regulation and expression. In many neuroscience studies, animal models such as mice are used, and accordingly, you may find that you must extract RNA from mouse brain tissue at some point or other.

There are unique challenges that arise when trying to extract RNA from mouse brain samples. This guide outlines the main precautions you should take to overcome these challenges and achieve successful RNA extraction.

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How to Keep a Lab Notebook
How to Keep a Lab Notebook
How To Guide

Our FREE guide will help you organize your experimental data effectively, enabling you to create a lab notebook that provides everything needed to give your work transparency and reproducibility.

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How to Become a Science Writer: 8 Tips to Guide You
How to Become a Science Writer: 8 Tips to Guide You
How To Guide

Download our free guide for tips on becoming a science writer, including organizing your time and creating your own brand.

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Chemiluminescence Western Blotting Technical Guide and Protocols
Chemiluminescence Western Blotting Technical Guide and Protocols
How To Guide

Download this free guide to learn about the types of considerations of chemiluminescence western blotting, how to optimize your western blots, and much more!

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Identifying Immune Cells – Human and Mouse Antigens
Identifying Immune Cells – Human and Mouse Antigens
How To Guide

Download this guide to discover how to build your own immunophenotyping and how to select which antigens are best to identify a specific cell type.

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4 Steps to Successful Compound Optimization on LC-MS/MS
4 Steps to Successful Compound Optimization on LC-MS/MS
How To Guide

Chemists need to determine and optimize parameters for instruments to enable detection of novel contaminants. This guide provides an easy reference for compound optimization with LC-MS/MS.

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Optimizing Your Sample Handling and Management
Optimizing Your Sample Handling and Management
How To Guide

Sample management in the laboratory can be complicated, procedures vary significantly depending on the identity of the samples. This free guide describes key considerations for sample handling and management.

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8 Steps to Successful SMRT Sequencing
8 Steps to Successful SMRT Sequencing
How To Guide

When Single Molecule, Real-Time (SMRT) sequencing was first released, it promised a huge shift in our approach to sequencing – moving away from methods that had up to that point been validated and entrenched in labs across the world. In this guide, PacBio's Nick Sisneros provides some insight into SMRT Sequencing and the tips and tricks that will ensure success in the template prep and sample preparation for use on this sequencing platform.

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8 Tips for Improving Your NGS Libraries
8 Tips for Improving Your NGS Libraries
How To Guide

For most laboratory workflows, you’re only as good as your starting material. This is particularly true for next-generation sequencing (NGS). Here are several tips and tricks to preparing NGS libraries that hold true across all applications.

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