Latest How To Guides

Messenger RNA (mRNA) therapy enables the body to make the proteins needed to prevent, treat or cure diseases but, unlike traditional biologics, mRNAs are large and delicate molecules that need to be protected by lipid nanoparticles (LNPs) on the journey to reach target cells.

The maintenance of proteostasis (the regulation of the proteome) is ensured by complex and interconnected pathways. Impaired proteostasis can lead to the accumulation of damaged or aggregated proteins, or excessive protein degradation.

Download this guide to learn about the barriers you’ll face on the road to creating the lab of the future and how you can start preparing today.

The journey to discovering novel drug targets starts with building a deep understanding of the underlying biology. To achieve this, researchers are increasingly looking to 3D cell cultures to bridge the gap between 2D cell cultures and in vivo animal models.

Download this guide to learn how you can improve your qPCR reagents, sample/template and quality control.

Maintaining the health of growing cell cultures is a demanding task made more difficult by the perpetual risk of loss through accidents or contamination. In addition, actively growing cell cultures are subject to age-related or environmentally-induced changes which can result in their ongoing evolution and potential loss.

This guide highlights the four major stages of targeted protein degradation, the challenges at each step, and the questions you should ask yourself to ensure your final product will result in a complete protein degradation.

Mitochondrial toxicity assessments are crucial to ensuring the safety and efficacy of candidate compounds during drug development.

Download this guide to discover tips on sample preparation, fluorescence, fluorochromes and your antigens, your cytometer and data analysis.

Download this guide to learn how to select the appropriate NGS method and sequencing platform, deal with samples of variable quality, and set up and manage the data analysis pipeline.