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When Single Molecule, Real-Time (SMRT) sequencing was first released, it promised a huge shift in our approach to sequencing – moving away from methods that had up to that point been validated and entrenched in labs across the world. In this guide, PacBio's Nick Sisneros provides some insight into SMRT Sequencing and the tips and tricks that will ensure success in the template prep and sample preparation for use on this sequencing platform.READ MORE
For most laboratory workflows, you’re only as good as your starting material. This is particularly true for next-generation sequencing (NGS). Here are several tips and tricks to preparing NGS libraries that hold true across all applications.READ MORE
Field spectroscopy enables scientists to measure how different materials interact with electromagnetic energy and therefore underpins the technology enabling us to view the world from the air or space. Here we explore some tips for perfecting your field spectroscopy skills.READ MORE
The CRISPR interference (CRISPRi) machinery is an efficient, reversible and specific genome regulating platform for transcription control, without altering the target DNA sequence. This guide includes key steps on implementing CRISPRi using dCas9 derived from Streptococcus pyogenes.READ MORE
While technological advances are reshaping the cell culture field, many basic steps are still to this day performed manually in laboratories. This guide highlights 10 tips for successfully developing cell culture assays.READ MORE
While the shift to 3D cell culture has been under way for the last decade, it is still evolving rapidly to meet the ever growing and dynamic pharmaceutical demand.
Here we provide tips which we deem essential for anyone carrying out 3D cell culture.