High-Performance Liquid Chromatography Troubleshooting

How To Guide

Last Updated: April 1, 2022

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Despite the fact that high-performance liquid chromatography is a mature technology and a lot of care is taken during method development, analysts often run into issues that not only put the data at risk, but also lead to wastage of expensive samples, chemicals and consumables.

Download this guide to discover how to prevent issues with:

Backpressure
Retention-time variability
Peaks and baselines

Meet the Author

Srividya Kailasam, PhD

Srividya completed her doctoral training in analytical chemistry at the Indian Institute of Technology, Madras. During her postdoctoral research in the United States, she worked on process analytical chemistry, analysis of toxic industrial chemicals and quantification of VOCs in biological matrices. After returning to India, Srividya joined Agilent Technologies in Bangalore, as an application scientist where she developed numerous LC, LC-MS and LC-MS/MS methods for the analysis of a variety of samples such as pharmaceuticals, bio-fluids, beverages and animal feed. She then moved to Thermo Fisher Scientific in Bangalore and worked as a subject matter expert for software development focused on the analysis of mass spectrometry data. Srividya started writing for Technology Networks in May of 2021.