Protein Degradation – A Guide to the Proteasome and Autophagy Systems
Proteostasis controls the fate of a protein from synthesis to degradation. When it’s impaired, it is associated with ageing and disease.
By understanding the underlying pathways behind protein degradation, researchers can develop therapeutic strategies that target neurodegenerative disorders, autoimmune diseases and cancers.
This guide explores the critical role of ubiquitin in two protein degradation systems, the ubiquitin-proteasome system (UPS) and the autophagy–lysosomal system (ALS), in proteostasis.
Download this guide to learn more about:
- The role of ubiquitin in protein regulation
- Targeting the ubiquitin proteasome system
- Using PROTACs to achieve targeted protein degradation