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Protein Degradation – A Guide to the Proteasome and Autophagy Systems

The maintenance of proteostasis (the regulation of the proteome) is ensured by complex and interconnected pathways. Impaired proteostasis can lead to the accumulation of damaged or aggregated proteins, or excessive protein degradation. Proteostasis is thus involved in pathologies such as cancer, autoimmune diseases and neurodegenerative disorders.

Download this guide to learn more about:

  • The ubiquitin proteasome system
  • The autophagy-lysosomal system
  • Targeted protein degradation