Laboratories face growing sample volumes and strict requirements for data integrity, and manual decapping methods can introduce inefficiencies and contamination risks. From biobanking to genomics and drug discovery, precision and consistency are critical. Without automation, throughput suffers and research timelines extend.
This guide explores how automated decapping enhances lab performance by reducing manual errors, preserving sample integrity, and simplifying workflow transitions.
Download this guide to discover
- How automation improves workflow efficiency in high-demand labs
- The key benefits of consistent, contamination-free sample handling
- Practical advantages for genomics, biobanking, and drug discovery workflows
Accelerating laboratory workflows with
automated decapping
Laboratories today face mounting challenges to enhance efficiency
and maintain sample integrity amid increasingly complex workflows.
Traditional capping and decapping methods, which often involve
manual tools like handheld cap removers or applying force by hand,
are labour intensive and error prone. These methods can lead to
sample contamination due to improper handling and variability
introduced by inconsistent handling techniques. To address these
challenges, many laboratories are turning to automated capping and
decapping solutions.
An automated decapper for maximum efficiency
The Thermo Scientific™ Capit-All™ Flex Automated Decapper
automates the capping and decapping process. This compact and
versatile device uses individual motors to apply or remove caps with
consistent and precise force, helpng ensure a uniform seal every
time. To enhance usability, the Capit-All Flex is equipped with a
seven-inch, angled touchscreen, allowing researchers to operate
with or without gloves for simplified interaction in diverse laboratory
environments. A built-in drip tray acts as a barrier between caps and
tubes after the decapping step, helping to prevent
cross-contamination. By automating these critical steps, the
Capit-All Flex helps to minimise human errors, making it an excellent
tool for today’s laboratories.
In addition to its operational efficiency, the Capit-All Flex is
compatible with Thermo Scientific™ Matrix™ and Nunc™
cryo-tubes in 96- and 48-format racks. Researchers can easily
switch between tube types without needing to change adapters,
helping reduce setup time and associated costs. This adaptability,
along with the flexibility to use the system as a standalone benchtop
unit or an integrated system, makes the Capit-All Flex particularly
advantageous for space-constrained labs that require robust and
reliable solutions to handle diverse workflows.
Expanding applications across research areas
The Capit-All Flex Automated Decapper addresses critical needs
across various research disciplines. In the expanding biobanking
sector, preserving biological samples with integrity is vital for
applications like biomarker discovery and disease monitoring.
The Thermo Scientific Capit-All Flex Automated Decapper cassette
enables switching between Matrix and Nunc cryotubes in 96- and
48-format racks without adaptors or downtime.The global biobanking market, estimated at $76.97 billion in 2023,
is projected to grow to $169.62 billion by 2033 (1). This growth
underscores the demand for reliable sample management tools
like the Capit-All Flex. By automating the decapping process, the
device helps researchers handle large sample collections with
minimal risk of contamination or degradation, helping ensure the
long-term usability of biological specimens. For example, when
managing collections for biomarker studies, consistent sealing
provided by the Capit-All Flex protects samples from
environmental fluctuations that could otherwise compromise
results. This allows bio-banks to meet increasing demands
efficiently, even with space and resource constraints.
Similarly, in genomics research, maintaining the integrity of DNA
and RNA samples is vital. Manual capping errors can lead to
contamination or degradation, jeopardizing sequencing accuracy.
With the ability to process both full and partial racks, the Capit-All
Flex helps ensure smooth transitions in high throughput
environments such as sequencing labs. For instance, for a
genomics lab processing thousands of DNA samples daily, the
Capit-All Flex minimizes variability in sample handling, reducing the
likelihood of compromised sequencing data. Its streamlined
design also minimizes setup complexity, enabling researchers to
focus on data generation and analysis instead of workflow
management.
Beyond biobanking and genomics, the drug discovery field also
benefits from automated sample handling solutions. The global
drug discovery market, valued at $24.84 billion in 2024, is
expected to reach $62.10 billion by 2033 (2). Laboratorians in this
field face immense pressure to accelerate pre-clinical research
and optimise workflows. and optimise workflows.
The Capit-All Flex addresses these challenges by automating
sample handling and expediting high throughput processes like
drug screening and toxicity testing. Consistent and error-free
handling of samples also helps to ensure the validity of drug
efficacy and safety evaluations (3). Together, these improvements
increase workflow efficiency, allowing researchers to progress
through preclinical stages more quickly.
Incorporating instruments like the Thermo Scientific Capit-All Flex
Automated Decapper enables laboratories to achieve higher
productivity, accuracy, and scalability. Whether preserving
bio-bank samples, streamlining genomic sequencing, or
optimizing workflows in drug discovery, the Capit-All Flex
addresses inefficiencies head-on. Its adaptable design, precision
engineering, and user-friendly interface make it an important tool
for modern research.
References
1. Biobanking Market Size to Attain Around US$ 169.62 Billion by 2033.
BioSpace (2024). at
biospace.com/biobanking-market-size-to-attain-around-us-169-62-billion-by
-2033
2. Research, S. Drug Discovery Market Size, Share and Trends by 2033. at
straitsresearch.com/report/drug-discovery-market
3. A Al Naam, Y. et al. The Impact of Total Automaton on the Clinical
Laboratory Workforce: A Case Study. J Healthc Leadersh. 14, 55–62 (2022).
Equipped with a seven-inch angled touchscreen and drip tray to prevent
contamination, the Thermo Scientific Capit-All Flex Automated Decapper
is an excellent solution for today’s laboratories.
The Thermo Scientific Capit-All Flex Automated Decapper is a
full-service, automated capping and decapping solution for 48- and
96-tube racks.
For Research Use Only. Not for use in diagnostic procedures. © 2026 Thermo Fisher Scientific Inc. All rights
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