CD47: Regulation of cellular phagocytosis in cancer, inflammation & neurobiology
Infographic Oct 11, 2017
CD47 is a cell surface ‘don’t eat me’ signal that has been shown to be important in detection and evasion of cancer cells, inflammation, neuronal pruning and other pathophysiological processes.
Blocking CD47 allows tumor cells to be recognized by phagocytes and this cell-cell interaction initiates a cascade of events resulting in tumor cell destruction. As such CD47 is an attractive target for the development of novel therapeutics.
Download this Infographic for an overview of the dynamics of CD47 signaling in the regulation of cancer, inflammation and neuronal pruning and methods to target this pathway for potential immunotherapies.
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The aim of personalized medicine is to a move away from the traditional “one size fits all” approach to the treatment of diseases – such as cancer. For patients where standard clinical options have been exhausted, novel personalized therapeutics may be required. Patient-derived cancer models, such as “organoids”, can help predict an individual’s response to a drug – both efficacy and toxicity – prior to administration.READ MORE