DIA vs DDA in Proteomics
Infographic Sep 03, 2019
Over recent years, liquid chromatography coupled to tandem mass-spectrometry (LC-MS/MS) has become the MS technology of choice for the high-throughput characterization of proteins and proteomes.
There are two modes of acquisition that can be used in LC-MS/MS experiments: the more traditional data dependent acquisition (DDA) mode, and the recently developed data independent acquisition (DIA) approaches, such as SWATH.
Download this infographic to gain an understanding of:
- The processes involved in an experiment using a DIA approach
- How DIA produces a higher number of quantified proteins in a shorter analysis period than DDA
Over recent years, the number of newly approved drugs brought to market has continued to decrease. Many drugs fail due to the fact they do not show efficacy at specific stages of the drug development pipeline, typically Phase II or Phase III. Subsequently, the pharmaceutical industry is facing pressures to optimize the drug discovery phase of the drug development pipeline, to avoid late-stage failures, and streamline the process. One approach to doing this is by adopting automation.READ MORE