mRNA therapeutics have gained significant attention and hold promise in various medical fields; however, they are not without their limitations. mRNA molecules are inherently fragile and scaling up production can be complex and expensive.
This infographic presents end-to-end solutions that support the entire mRNA therapeutics workflow. From template generation with high-quality DNA strings to plasmid production and purification, collaborating with an experienced services provider can accelerate your discoveries to successful commercialization.
Download this infographic to learn more about:
- The crucial role of plasmids in mRNA therapeutics and how to scale up their production
- Innovative chromatography solutions for simplifying mRNA purification
- Analytical testing methods that meet regulatory requirements
mRNA therapeutics workflow Your journey through mRNA therapeutic development from discovery to commercialisation. End-to-end solutions to support your mRNA therapeutics workflow. 1 TEMPLATE GENERATION High quality double stranded DNA strings or plasmid constructs are essential building templates during mRNA in vitro transcription. 2 PLASMID PRODUCTION Plasmids are the building blocks needed to manufacture mRNA therapeutics. Plasmid production takes place in a microbial fermentation process and our product solutions are designed to scale up the production from development to commercial phase. 3 mRNA PURIFICATION Simplify your purification process with our innovative chromatography solutions specifically designed to improve the downstream purification of mRNA molecules. 6 mRNA PRODUCTION A comprehensive portfolio of nucleotide, enzymes, and capping solutions for mRNA production designed for seamless progression from preclinical development to commercial manufacturing. 5 PLASMID PURIFICATION Achieve faster process development with our product solutions designed to scale production whilst isolating, purifying and extracting high quality plasmid DNA. 4 With Thermo Fisher Scientific, you have the support to accelerate mRNA therapeutics from discovery to commercialisation with our comprehensive portfolio of products & services proven to meet critical process, scale, quality and regulatory needs. A B FORMULATION Once the mRNA molecules have been purified, they are ready for formulation. The mRNA molecules can be complexed with the lipid reagents to mediate ecient delivery to the target cells. Bring your formulation process together seamlessly with an extensive range of standard and customised bioprocess containers and fluid transfer products. ANALYTICAL TESTING Detection of impurities and contaminants is critical in the therapeutics manufacturing process. We provide rapid analytical assays with total workflow solutions to align with regulatory requirements, from evaluation through to validation and approval. 8 FILL AND FINISH, AND STORAGE After the mRNA has been formulated with lipid carriers, Thermo Fisher Scientific provides drug product fill, finish, and storage solutions. 9 7 Connect with us to bring your mRNA therapeutics development to commercialisation with confidence CONTACT US For Research Use or Further Manufacturing. Not for diagnostic use or direct administration into humans or animals.