Top-down vs. Bottom-up Proteomics

Infographic

Published: November 28, 2018

Top-down vs. Bottom-up Proteomics content piece image

Proteomics is an essential tool for the diagnosis, prognosis, and development of disease – since most diseases manifest at the protein activity level. In addition, it also plays a crucial role in drug discovery and development, helping to identify potential therapeutic targets.

The ’bottom-up’ approach has historically been the most commonly used workflow in proteomics, however, more recently the use of ‘top-down’ methods have begun to gain momentum.

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Review both approaches
Learn the main advantages and disadvantages of each approach
Discover the applications each approach is best suited for

Meet the Authors

Laura Elizabeth Lansdowne

Managing Editor

Laura Lansdowne is the managing editor at Technology Networks, she holds a first-class honors degree in biology. Before her move into scientific publishing, Laura worked at the Wellcome Sanger Institute and GW Pharma.

Tiffany Quinn

After obtaining a bachelor in neuroscience from the University of Leeds, Tiffany joined Technology Networks to pursue a career in science communication as a custom content producer and manager. She has helped grow the company’s custom content services through creating high-quality and engaging content for client’s target audiences. Tiffany left TN in 2023 to pursue other career goals.