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Researchers Find Inhibiting One Protein Destroys Toxic Clumps Seen in Parkinson's Disease
Researchers Find Inhibiting One Protein Destroys Toxic Clumps Seen in Parkinson's Disease
News   Nov 17, 2018

“To our knowledge, these data are the first to elucidate the role of USP13 in neurodegeneration.”

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Ketone Shuttle Coordinates Response to Liver Fibrosis
Ketone Shuttle Coordinates Response to Liver Fibrosis
News   Nov 16, 2018

A metabolite shuttle, or dialogue, provides a connection between hepatocyte and macrophage cell types in the liver and helps protect against tissue fibrosis.

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Molecular Mechanisms of Ancient Herbal Remedies
Molecular Mechanisms of Ancient Herbal Remedies
News   Nov 16, 2018

Analysis of leaf extract reveals novel chemistry for therapeutic ion channel activation.

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Scorpion Venom Can Shuttle Drugs into the Brain
Scorpion Venom Can Shuttle Drugs into the Brain
News   Nov 16, 2018

Researchers at IRB Barcelona modify chlorotoxin—a small protein present in scorpion venom with blood-brain barrier permeability—to transport drugs into the brain.

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Leukemia Stem Cells Rely on Amino Acids for Survival
Leukemia Stem Cells Rely on Amino Acids for Survival
News   Nov 16, 2018

Clinically relevant eradication of leukemia stem cells could be achieved with drugs that target their metabolic vulnerabilities.

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New Inflammation Inhibitor Discovered
New Inflammation Inhibitor Discovered
News   Nov 16, 2018

A multidisciplinary team of researchers led from Karolinska Institutet in Sweden have developed an anti-inflammatory drug molecule with a new mechanism of action.

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Drug Candidate Could Recover Vocal Abilities Lost to ADNP Syndrome
Drug Candidate Could Recover Vocal Abilities Lost to ADNP Syndrome
News   Nov 16, 2018

A new Tel Aviv University study finds that the drug candidate CP201, also known as NAP, may improve vocal communication abilities that are underdeveloped in Activity-dependent neuroprotective protein (ADNP) patients.

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Membrane Proteins Ejected Directly from Cell Membrane to Mass Spec
Membrane Proteins Ejected Directly from Cell Membrane to Mass Spec
News   Nov 16, 2018

A new approach to analyzing cell membrane proteins in situ could revolutionize the way in which we study diseases, such as cancer, metabolic and heart diseases.

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Blood Test Detects and Classifies Cancer at its Earliest Stages
Blood Test Detects and Classifies Cancer at its Earliest Stages
News   Nov 15, 2018

Cancer scientists have combined "liquid biopsy," epigenetic alterations and machine learning to develop a blood test to detect and classify cancer at its earliest stages.

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'Bubble Baby' Study Calls for Neonatal Screening
'Bubble Baby' Study Calls for Neonatal Screening
News   Nov 15, 2018

As therapeutic options become more advanced, the case for neonatal screening strengthens.

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