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MIT Team Recreates Complex Fungal Compound With Anticancer Potential
MIT researchers have synthesized verticillin A, a complex fungal compound discovered more than 50 years ago and long recognized for its anticancer potential. The compound’s fragile structure and precise stereochemistry make it difficult to produce.
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Machine Learning Helps Researchers Predict New England Floods
Researchers have used machine learning to aggregate nearly five decades of weather data to better understand the factors that lead to New England flooding.
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Combination Therapy Extends Survival in Patients With Aggressive Brain Cancer
A Phase 3 trial found that combining eflornithine with lomustine significantly improved survival for patients with recurrent grade 3 IDH-mutant astrocytoma, extending life by nearly a year compared with standard therapy.
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PFAS Exposure May Limit Improvements in Blood Sugar After Bariatric Surgery
Researchers studying the link between PFAS exposure and changes in markers of type 2 diabetes in teens who underwent bariatric surgery found that “forever chemicals” exposure was linked to worse metabolic outcomes five years later.
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Light-Activated Protein Therapy Kills Cancer Cells by Increasing Alkalinity
When exposed to green light, the protein AR3 increases alkalinity in cells, disrupting cellular functions and causing apoptosis.
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New Spatial Transcriptomics Toolkit Sets Quality Standards
The Spatial Touchstone project created a curated multi-tissue repository, standardized protocols and open-source tools to address quality gaps in spatial transcriptomics. The initiative enables researchers to evaluate sample quality.
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Electronic Sensor Rapidly Determines Fish Freshness
Discover how a simple electronic device rapidly assesses hypoxanthine in fish, offering a more reliable indicator of freshness and spoilage.
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Noninvasive Imaging Could Spare Diabetes Patients From Daily Finger Pricks
A new non-invasive glucose monitor utilizes Raman spectroscopy, offering pain-free diabetes management solutions for patients.
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Researchers Fix Major Flaw in How We Map Animal Traits
NC State scientists created a statistical framework that dramatically improves fine-mapping in livestock, where relatedness obscures genetic signals. The method reliably identifies variants tied to growth, reproduction and efficiency.
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Key Enzyme Identified in Pneumonia-Related Heart Damage
Researchers identified a bacterial enzyme that enables Streptococcus pneumoniae to invade heart cells and cause damage, explaining why some pneumonia patients suffer cardiac complications.
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