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Cracking the Synthetic Code of Rare Molecules
A research team has produced two molecules that are usually only formed by microorganisms found in contaminated wastewater in an abandoned mine in South Korea. The approach could pave the way for new types of drugs.
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Nanoparticle Could Lead to More Powerful Vaccines
Researchers have designed a new nanoparticle adjuvant that may be more potent than others now in use. Studies in mice showed that it significantly improved antibody production following vaccination against HIV, diphtheria and influenza.
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First Single-Cell Atlas of the Human Eye Constructed
The cell-by-cell atlas will help in the study of eye disorders and development of cell therapy to replace damaged eye tissue.
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Tri-Layered Skin Equivalents Bioprinted
Researchers have developed an approach to print skin equivalents, which may play a future role in facilitating the healing of chronic wounds. The technique is the first of its kind to simulate three layers of skin: the hypodermis, the dermis and the epidermis.
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Viagra Prescription Associated With a 69% Reduction in Alzheimer’s Risk
A study looking at the potential of repurposing licensed drugs for the treatment of Alzheimer’s disease has identified the erectile dysfunction drug sildenafil, trade name Viagra, as a candidate for future analysis.
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How Some Tissues Can “Breathe” Without Oxygen
Research shows that when cells are deprived of oxygen, another molecule called fumarate can step in and serve as a terminal electron acceptor to enable mitochondrial function in this environment.
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Incision-Free Brain Surgery Uses the Power of PING
Researchers have developed a noninvasive way to remove faulty brain circuits that could allow doctors to treat debilitating neurological diseases without the need for conventional brain surgery.
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Why the Brain Guzzles Fuel Even While Resting
Pound for pound, the brain consumes vastly more energy than other organs, and remains a fuel-guzzler even when neurons are not firing neurotransmitters to each other. Now researchers have found that the process of packaging neurotransmitters may be responsible for this energy drain.
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Making Sense of Food Textures
Our understanding of how microscopic structure and changes in the shape of food affect the texture of food remains underdeveloped. Researchers have conducted a series of experiments relating the study of how soft solids and some liquids deform to texture.
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Tackling Lassa Virus Infection With Structural Clues
Lassa fever is listed as a significant public health threat with high epidemic potential and no effective countermeasures. Researchers have now used structural biology to detail nine structures of the Lassa viral polymerase in different functional configurations.
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