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Obtaining Crystal Structures of Drug Compounds With Microcrystal Electron Diffraction
Researchers usually use X-ray diffraction in the drug development process. Researchers have shown how microcrystal electron diffraction (MicroED) is growing to obtain the structures of potential pharmaceuticals.
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Body’s Reaction to Contact Allergens More Complex Than Previously Thought
About one in five Danes react to contact allergens, but some patients develop rashes and itching much faster than others. Previously the scientists were unable to explain why, but now researchers have outlined an entire new subgroup of allergic reactions which explains these early skin reactions.
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How Drug Resistance Arises in Lung Cancer
When prescribed antibiotics for a bacterial infection, the patient is usually required to finish the entire treatment, even when symptoms go away. This is to ensure the drugs kill off any remaining bacteria. Scientists have investigated a similar problem that occurs in some lung cancers.
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Movement of Microplastics in the Ocean Predicted by Mathematical Model
A new model tracking the vertical movement of algae-covered microplastic particles offers hope in the fight against plastic waste in our oceans.
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Testing Blood Levels of ACE2 Species Could Help To Monitor SARS-CoV-2 Infection
A blood test that quantifies the protein ACE2, the cellular protein which allows entry of the virus into cells, as well as ACE2 fragments, produced as a result of interaction with the virus, could be an effective method for monitoring SARS-CoV-2 infection.
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Simulations Reveal How Cyclic Peptides Diffuse Into Cells
Scientists have developed a computational method to predict the cell membrane permeability of cyclic peptides using a supercomputer. The approach could be a useful tool for the design and discovery of cyclic peptide drugs.
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Mechanical Stimuli Influence Organ Growth
Researchers have used organoids to investigate the effect of mechanical stimuli on organ growth.
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New Insights Into the Journey of Eggs and Embryos in the Fallopian Tube
Looking to shed new light on the dynamics of eggs prior to fertilization and embryo transport preceding implantation, researchers developed a novel imaging approach that has allowed them to see eggs and embryos as they move along the fallopian tube in a live animal.
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mRNA From COVID-19 Vaccine Is Not Transferred Through Mother’s Breast Milk
Researchers have analyzed the breastmilk of lactating women that had received an mRNA-based COVID-19 vaccine. None of the samples showed a detectable level of vaccine mRNA in the breastmilk.
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How Cells Keep Gene Silencing in Check
Long considered ‘junk’, non-coding RNAs have emerged as gene silencing regulators. Working in yeast, researchers have identified more than 20 mutations that enable RNA-mediated gene silencing.
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