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Finding Drugs To Target Critical Enzymes Called Racemases
Scientists have explored racemases, enzymes linked to certain cancers that are critical to cell function, and have proposed new strategies for finding drugs that neutralize these enzymes.
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Food Scraps Get a Second Life in Construction
Most people don't think much about the food scraps they throw away; however, investigators have developed a new method to reduce food waste by recycling discarded fruit and vegetable scraps into robust construction materials.
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A Novel Class of Radiosensitizers for Glioblastoma
Researchers have shown that the calcium channel blocker (CCB), mibefradil, inhibits DNA repair independent of its CCB activity. The findings could lead to a new class of mibefradil-based DNA repair inhibitors for glioblastoma.
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T Cells Make Mistakes in Telling Friend From Foe
When it comes to distinguishing a healthy cell from an infected one that needs to be destroyed, the immune system’s killer T cells sometimes make mistakes. This discovery upends a long-held belief among scientists that T cells were nearly perfect at discriminating friend from foe.
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Fungi and Bacteria Can Activate Genes Linked to Head and Neck Cancer
An in vitro study demonstrates how fungi and bacteria can activate genes linked to head and neck tumors. The researchers revealed that the metabolism of biofilms stimulates cancer cells by favoring specific cell signaling pathways associated with the development of tumors and drug resistance.
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Human Salivary Proteome Wiki Could Help To Transform Diagnostic Testing
To improve the development of new saliva-based diagnostic tests and personalized medicine, the National Institute of Dental and Craniofacial Research has supported the development of the Human Salivary Proteome Wiki, the first public platform that catalogs and curates data on each of the thousands of proteins within our saliva.
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Non-Hallucinogenic Psychedelic Analog Reverses Effects of Stress in Mice
A compound with a similar structure to the psychedelic drug ibogaine, but lacking its toxic and hallucinogenic effects, has been shown to reverse the effects of stress in mice.
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Study Deepens Our Understanding of Cellular Mechanosensing
An interdisciplinary team seeks to better understand how the mechanical properties of cells operate in the body and how pathologies can disrupt these processes.
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New Feature That Contributed to Modern Humans Evolving Away From Neanderthals Is Discovered
The team discovered that the modern human genome undergoes mutation which makes the adenylosuccinate lyase enzyme less stable, leading to a decrease in purine synthesis. This mutation did not occur in Neanderthals, so the scientists believe that it affected metabolism in brain tissues and thereby strongly contributed to modern humans evolving into a separate species.
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Investigating How Wave Action Impacts Ocean Debris Distribution
Scientists have investigated how waves transport floating ocean debris while including, for the first time, the effects of an object’s size, buoyancy, and inertia on its transport. This may help to answer questions on the fate of plastics in the oceans.
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