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Coaxing Single Stem Cells Into Specialized Cells

Researchers at the University of Illinois Chicago have developed a unique method for precisely controlling the deposition of hydrogel, which is made of water-soluble polymers commonly used to support cells in experiments or for therapeutic purposes.
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Offspring of Mice Fed Imbalanced Diets Appear "Programmed" for Obesity

Pregnant mice fed a diet high in omega-6 fats and low in omega-3 fats produce offspring that go on to exhibit “hedonic”—pleasurable but excessive—levels of consumption of hyper-caloric diets, according to researchers at Hiroshima University.
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Could Longer Gestation Be the Cause of Bigger Brains?

The neocortex, the largest part of our brain, enables us to speak, dream and think. During human evolution, the size of the neocortex has increased dramatically. Studying different strains of mice, researchers have identified a possible cause of neocortex expansion. which connects gestation, neurogenesis and neocortical size.
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Why Does Pain in Osteoarthritis Change Over Time?

The pain experience in patients with knee osteoarthritis changes over time. To understand why, researchers reviewed data about the pain experience of 2,794 older adults with or at risk of knee osteoarthritis.
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Common Class of Drugs Linked to Increased Cognitive Decline

A team of scientists, led by researchers at University of California San Diego School of Medicine, report that a class of drugs used for a broad array of conditions, from allergies and colds to hypertension and urinary incontinence, may be associated with an increased risk of cognitive decline, particularly in older adults at greater risk for Alzheimer's disease (AD).
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Dorsal Rooth Ganglion Pathology Associated With AAV Gene Therapy in Animal Model

A meta-analysis of non-human primate (NHP) studies showed that adeno-associated virus (AAV) gene therapy often caused dorsal root ganglion (DRG) pathology. There were no clinical effects.
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A Peek Into the Black Box: How Do Neural Networks "Think"?

Face recognition, object detection, and person classification by machine learning algorithms are now in widespread use. However, machine learning is like a black box: computers take decisions they regard as valid but it is not understood why one decision is taken and not another. An new study has taken a peek into the black box of neural networks.
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Repulsing Neurons Help Create Columns in the Brain

The brain's structure has columnar features, which are hypothesized to arise from nerve cells stemming from the same parent cell, initially forming radial units. How exactly this process unfolds at the molecular level remains unexplained, however. Now, an important insight has been gleaned from a study of the fly brain.
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Research Team Lay Groundwork for Fair Distribution of a COVID-19 Vaccine

Nineteen global health experts from around the world have proposed a new, three-phase plan for vaccine distribution — called the Fair Priority Model — which aims to reduce premature deaths and other irreversible health consequences from COVID-19.
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Vaccine Shows Protection Against SARS-CoV-2 in Animals

In a new study, researchers demonstrated that a candidate COVID-19 vaccine elicited robust immune response in Syrian golden hamsters and prevented severe clinical disease — including weight loss, pneumonia and death.
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