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Pre-Diabetes Discovery Marks Step Towards Precision Medicine
Pre-Diabetes Discovery Marks Step Towards Precision Medicine
News   Nov 23, 2017

Identification of three molecules that can be used to accurately assess pre-diabetes – a key predictor of conditions such as diabetes and high blood pressure – has brought precision medicine for humans a step closer.

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Novel Chemistry Technique Simplifies Late-Stage Modification of Drug Compounds
Novel Chemistry Technique Simplifies Late-Stage Modification of Drug Compounds
News   Nov 23, 2017

Chemists at The Scripps Research Institute (TSRI) have invented a technique that overcomes a long-standing problem in organic chemistry and should streamline the process of discovery and development for many new drugs.

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Protein "Intentionally" Terminates own Synthesis by Destabilizing Synthesis Machinery — the Ribosome
Protein "Intentionally" Terminates own Synthesis by Destabilizing Synthesis Machinery — the Ribosome
News   Nov 23, 2017

A research group has discovered that a protein, during its synthesis, may destabilize the structure of the ribosome and end its own synthesis prematurely, and found that this phenomenon is used for adapting the cell to its environment.

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Meningococcal Vaccine Could Protect Against 91% of Targeted Bacterial Strains
Meningococcal Vaccine Could Protect Against 91% of Targeted Bacterial Strains
News   Nov 23, 2017

“We are very pleased to see that it looks like the vaccine has the potential to cover most of the strains of meningococcal Group B bacteria currently circulating in the U.S.,” said lead study author Gowrisankar Rajam, Ph.D.

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Antibiotic Resistance: Researchers Succeed in Blocking Genes of Resistance
Antibiotic Resistance: Researchers Succeed in Blocking Genes of Resistance
News   Nov 23, 2017

Scientists have come up with a novel approach to block the transfer of resistance genes between bacteria via plasmids. Libraries of small chemical molecules were screened for those that bound an essential component of the plasmid transfer machinery. Analysis by X-ray crystallography revealed the exact binding site of these molecules.

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A Structural Clue to Attacking Malaria’s ‘Achilles Heel’
A Structural Clue to Attacking Malaria’s ‘Achilles Heel’
News   Nov 23, 2017

Researchers have shed light on how the human immune system recognizes the malaria parasite though investigation of antibodies generated from the RTS,S malaria vaccine utilising X-ray crystallography and other sophisticated imaging technologies. This work could boost the development of a more potent vaccine against the global killer.

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Water Cooling for the Earth's Crust
Water Cooling for the Earth's Crust
News   Nov 23, 2017

By applying a new analysis method, researchers have now discovered that sea water can penetrate to depths of more than 10 kilometres below the seafloor. This result suggests a stronger cooling effect on the hot mantle.

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Existing 20-year-old Multiple Sclerosis Drug Effective Against Multi-resistant Bacteria
Existing 20-year-old Multiple Sclerosis Drug Effective Against Multi-resistant Bacteria
News   Nov 23, 2017

A widely-used and twenty-year-old medicine used to treat multiple sclerosis can also beat a type of multi-resistant bacteria for which there are currently only a few effective drugs.

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A More Effective Alternative to RNAi, CRISPR for Studying Protein Function
A More Effective Alternative to RNAi, CRISPR for Studying Protein Function
News   Nov 22, 2017

Trim-Away is a novel method enabling researchers to directly and rapidly destroy any protein in any kind of cell.

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RNAi-based Drug Shows Promise as Treatment for Chronic Hepatitis B
RNAi-based Drug Shows Promise as Treatment for Chronic Hepatitis B
News   Nov 22, 2017

The novel therapy by Arrowhead Pharmaceuticals uses a mechanism called RNA interference to reduce the surface antigens created by chronic HBV infections.

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