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Like Film Editors and Archaeologists, Curious Biochemists Piece Together Genome History
Old-school Hollywood editors cut unwanted frames of film and patched in desired frames to make a movie. The human body does something similar--trillions of times per second--through a biochemical editing process called RNA splicing. Rather than cutting film, it edits the messenger RNA that is the blueprint for producing the many proteins found in cells.
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New System Keeps Heart Tissue Alive Longer to Enable Extensive Drug Testing
Researchers have developed an easily reproducible system that enables them to keep slices of human hearts alive for a longer period of time, allowing more extensive testing of new drugs and gene therapies.
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Two Drug Targets Discovered for Deadly Lung Cancer
Researchers have discovered precisely why inactive LKB1 results in lung cancer development. Their new paper highlights how LBK1 communicates with two enzymes that suppress inflammation in addition to cell growth, to block tumor growth. These findings could lead to new therapies for NSCLC.
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Discovery of New Liver Cell Could Mean Liver Transplants Become Redundant
Scientists have identified a new type of cell called a hepatobiliary hybrid progenitor (HHyP), that forms during our early development in the womb. Surprisingly, HHyP also persists in small quantities in adults and these cells can grow into the two main cell types of the adult liver (Hepatocytes and Cholangiocytes) giving HHyPs stem cell-like properties.
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Genetic Screen Identified Genes That Protect Cells From Zika Viral Infection
A new Tel Aviv University study uses a genetic screen to identify genes that protect cells from Zika viral infection. It may one day lead to the development of a treatment for the virus and other infectinos.
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Microbial Manufacturing Accelerates Precision Agriculture
New research which focuses on precision agriculture, revolutionizes the creation of genetic material, enabling drastically accelerated development of key microbial factories for urban farming in Singapore.
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The "Sushi-like" Molecules That Direct Synapse Remodeling
Synapses between nerve cells in the brain undergo constant remodeling, which is the basis of learning. An Ludwig-Maximilians-Universitaet (LMU) in Munich team has now traced the molecules that direct remodeling and shown that they circulate in the living cell like running sushi.
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Stem Cell Therapy Furthers Research for Infants With Congenital Heart Disease
A Phase I clinical trial is the first research monitored by the Food and Drug Administration that demonstrates the potential of regenerative therapy for hypoplastic left heart syndrome through collecting, processing and injecting an infant's own stem cells directly into the heart at the time of surgery.
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LRH-1's Positive and Negative Roles in Inflammation
The role that the LRH-1 protein plays in the immune system has been discovered. Inhibiting this protein could help treat inflammatory diseases.
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Brains Sync Up During Music Therapy
For the first time researchers have been able to demonstrate that the brains of a patient and therapist become synchronised during a music therapy session, a breakthrough that could improve future interactions between patients and therapists.
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