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Checkmate for Hepatitis B in the Liver
Chronic infection with the hepatitis B virus has been conquered in a mouse model, thanks to the work of German researchers and T cell therapy.
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Mitochondria - When Friends Become Enemies
Researchers have discovered a new mechanism by which cells communicate in inflammatory processes. This involves endogenous mitochondria released from white blood cells turning into initiators of inflammation. It is as if friends turn into enemies.
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“Virtual Biopsy” Device Developed to Detect Skin Tumors
A new "virtual biopsy" device has been developed that uses sound vibrations and pulses of near-infrared light to quickly determine a skin lesion's depth and potential malignancy without using a scalpel.
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Using Third-party Apps to Analyze Personal Genetic Data
More and more consumers are using services like 23andMe to learn about their genetic blueprint. Included with most of these services is the ability for users to download their "raw" genetic data, which can be further analyzed using third-party apps. But little is known about how and why consumers are using these apps, or about a variety of potential risks associated with these apps, until now.
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Human Blood-Brain Barrier Chip Aids Development of Brain-targeting Drugs
A microfluidic organ chip model of the human blood-brain barrier, that recapitulates in vivo barrier functions, offers a new preclinical tool for development of brain-targeting therapeutics.
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Vaccine Drives Antibodies to Target Tau Tangles in Mice
A vaccine pioneered by virus-like particles induced a robust and long-lived antibody response to tau protein in mice, reducing soluble and insoluble species of Tau in the hippocampus and cortex.
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Susceptibility to Endocrine Disruptors May Depend on Your Genes
By identifying the genetic causes of susceptibility to endocrine disruptors, researchers highlight a fundamental inequity towards the toxicity induced by these products that are found everywhere in our environment.
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CRISPR-associated Transposase System: New Capabilities in Gene-editing
A team led by researchers from Broad Institute of MIT and Harvard, and the McGovern Institute for Brain Research at MIT, has characterized and engineered a new gene-editing system that can precisely and efficiently insert large DNA sequences into a genome.
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World’s First Reported Spontaneous Clearance of HIV, Without Treatment
In 1981, a patient from Sydney was transfused with a weakened form of HIV-1 when he received a blood transfusion following a motorbike accident. After controlling his infection for more than 30 years, he appears to have cleared his infection altogether – without therapy.
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Superfast "Metagenomic" Test Helps Diagnose Critically Ill Patients
In an analysis of the real-world impact of a pioneering test called metagenomic next-generation sequencing (mNGS), developed by UCSF scientists to diagnose patients with mysterious inflammatory neurological conditions, the technique was shown to identify infections better than any standard clinical method.
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