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Vision Begins Before We Actually See Anything
How does vision work, and what happens in the brain during the process? As simple as this question may sound, it has yet to be scientifically clarified in full. New research has now been able to show that the distribution of the two most important neurotransmitters in the brain changes as soon as we open our eyes, regardless of whether we actually see anything
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Healing Bone Fractures with 3D Printing and Stem Cells: Watch This Space
The U.S. Department of Defense has awarded a five-year $2 million grant to support studies on how to heal bone fractures using a combination of 3D printing and adult stem cells.
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Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery?
Researchers from the University of Manchester (United Kingdom) explore recent developments and strategies for targeting the NLRP3 inflammasome as a potential therapeutic target in acute and chronic neurological and neurodegenerative diseases, and offer perspective on how this field may develop in the future.
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Leukemia Epigenetics in Focus
Some severe forms of leukemia develop because proteins on the epigenetic level lose their regulative function. Now, in a broad international collaboration, UK researchers have identified molecules that can effectively inhibit the dysregulated proteins.
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Stem Cells and Inflammation: Therapeutic Potential Explored
A type of adult stem cell found in a variety of tissues can be manipulated to enhance tissue regeneration and potentially treat inflammatory diseases.
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Drug Development Stakeholders Call for Improved Pharmaceutical Testing
Drug development stakeholders from private and public sectors, including researchers, academics, and representatives from the pharmaceutical industry and advocacy groups, have joined together to call for a significant and urgent shift to prioritize predictive, human-based nonclinical tests.
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The See-Through Fruit Flies
The nervous system of an animal can be studied by cutting it up into thin layers - however this inevitably leads to the destruction of the cellular structures in the tissue. A far more elegant method is the so called optical "clearing" of the various tissues using chemical processes that make the animal transparent. A clearing method has now been developed that can be applied to insects.
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Fighting Obesity: Drug Turns White Fat Brown
Our bodies contain two types of fat: white fat and brown fat. While white fat stores calories, brown fat burns energy and could help us lose weight. Now, scientists have found a way of making the white fat ‘browner’ and increasing the efficiency of brown fat.
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FDA Approves Drug That Targets Key Genetic Driver of Cancer
Imagine one drug that can target and kill malignant cells for some patients with many types of cancer. A new drug called Vitrakvi (larotrectinib), now approved by the FDA, shows promise of doing just that for both adults and children with a variety of sometimes rare cancers that share one specific genetic mutation.
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Possible Neuronal Dysfunction Marker: Abnormal Oscillatory Brain Activity
Individuals potentially in the early stages of Alzheimer’s disease (mild cognitive impairment) and those with a rare form of language dementia (primary progressive aphasia) exhibited sluggish brainwaves and subtle signs of damage in the brain regions responsible for memory and planning.
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