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Targeting MC1R in Metastatic Melanoma

A University of Colorado Cancer Center study published in the journal Science Translational Medicine describes a genetic change common to 80% of human melanomas, the most deadly form of skin cancer, and also describes a molecule that seeks out cells marked by this genetic change.
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Single-cell Survey of Human Placenta in First-Trimester

A comprehensive single-cell survey of both fetal and maternal cells that are present during the first trimester could inform further research into a variety of pregnancy complications.
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Small Molecule Promotes Removal of Excess Cholesterol

Researchers have determined the structure of an enzyme critical for the removal of excess cholesterol from the body, and bound to a chemical that boosts its activity, paving the way for potential new therapeutics to treat heart and kidney failure.
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DNA With a Twist: Discovery Could Further Antibiotic Drug Development

DNA replication is vital to all lifeforms, but in some organisms it can be prevented by twists in the DNA sequence. If too many supercoils are allowed to build up, cells will die. DNA gyrase, which is found in bacterial cells but not human cells, relaxes the twists to allow DNA replication to continue as normal. This process is of particular interest to drug developers because if DNA gyrase can be successfully interrupted the bacteria will die and the threat of infection to the host prevented.
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AI System Accelerates Search for Cancer Discoveries

Searching through the mountains of published cancer research could be made easier for scientists, thanks to a new AI system. The system, called LION LBD has been designed to assist scientists in the search for cancer-related discoveries.
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Weighing Up Whole Virus Capsids

The mass of a whole bacteriophage virus capsid has been measured using novel mass-spectrometry technology based on nanomechanical resonators, a feat previously beyond technical capabilities.
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Beware of Evening Stress

Stressful events in the evening release less of the body’s stress hormones than those that happen in the morning, suggesting possible vulnerability to stress in the evening.
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What's On the Menu?

Cows eat grass. It seems simple enough. But just which kind of grass cows and their vegetarian comrades munch on can influence the entire ecosystem.
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Corals and their Microbiomes Evolved Together

Fresh insight in the fight to save the Earth’s embattled coral reefs has shown that corals and the microbes they host evolved together.
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Youtube Videos on Prostate Cancer: Majority are Misleading or Biased

The study of the 150 most-viewed YouTube videos on prostate cancer found that 77 percent had factual errors or biased content in either the video or its comments section.
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