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To monitor biomarkers informing about the responsiveness of immune cells to the therapy, first, interstitial skin fluid is sampled with microneedles from the lesions, and then biomarkers contained in it quantified with ultra-sensitive Simoa assays.
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Microneedle Platform Enables Minimally Invasive Monitoring of Skin Cancer Immunotherapy

Microneedles and ultra-sensitive, single-molecule measurements allow for the monitoring of protein biomarkers in responses to a combination immunotherapy against melanoma.
An illustration of hands removing the bases in a DNA molecule.
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Gene Therapy Restores Neural Connections in Hurler Syndrome

A new study is the first to demonstrate the ability for gene therapy to repair neural connections for those with the rare genetic brain disorder known as Hurler syndrome
Red blood cells flow through a blood vessel.
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DNA-Based Drug Targets Blood Clots

The widely-used anticoagulant heparin can have potentially fatal side effects, so researchers have developed a new DNA-based drug to target blood clots.
Salmonella bacteria.
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"Private Nutrients" Allow Pathogenic Salmonella To Coexist and Thrive

The ability to utilize a single alternative food source is all it takes for diarrhoea causing Salmonella bacteria to bloom when a gut is already colonized by a closely related strain. This coexistence enables the exchange of antibiotic resistance.
A diagram showing how the force sensor works.
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Inner Forces of Cells Studied With Novel Tool

A new sensor has been developed that can measure intracellular forces and mechanical strains, bringing new insights to the mechanics behind cancer.
A human brain.
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How Do Neurons Encode Behavior in Simple Animals?

MIT researchers model and map how neurons across the tiny brain of a C. elegans worm encode its behaviors, revealing many new insights about the robustness and flexibility of its nervous system.
Double helix structure of DNA.
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Ancient Genes Could Affect the Development of Neurodegeneration

It has been suspected for some time that viral infections contribute to the genesis and development of neurodegenerative diseases. Laboratory studies now suggest a mechanism that does not require infection by external pathogens.
an astronaut inserting blood samples for MARROW into the Minus Eighty-Degree Laboratory Freezer aboard the ISS.
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Space Travel Depletes Red Blood Cells but the Body Can Replenish Them Back

A study of 14 astronauts suggests that even though space travel destroys red blood cells and bones, the body manages to restore them after returning to Earth thanks to the fat stored in the bone marrow.
A woman holding a vape and a mug in her hands.
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Largest US Vape Study Shows Use as Anti-Smoking Aid

E-cigarette usage nudged people toward quitting smoking – even people who had entered the trial saying they had no intention of quitting.
A satellite in space.
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Gallium Oxide Semiconductors Produce Tough Electronics Suitable for Space

The electronic circuits in space probes need to be able to withstand exposure to radiation and huge temperature ranges. A research team is investigating whether gallium oxide could provide the answer.
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