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Astrocytes Keep the Brain's "Internal Shield" Healthy
News   Sep 22, 2020

In a study with potential impacts on a variety of neurological diseases, researchers have provided the first experimental evidence from a living organism to show that an abundant, star-shaped brain cell known as an astrocyte is essential for blood-brain barrier health.

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CRISPR-Based Malaria Testing on the Fly
News   Sep 22, 2020

A multi-disciplinary research collaboration created a field-applicable, ultrasensitive diagnostic assay that specifically detects DNA sequences from all Plasmodium species in symptomatic and asymptomatic malaria.

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Dual CAR T Cell Immunotherapy Fights HIV Infection in Humanized Mice
News   Sep 22, 2020

A recent study published in the journal Nature Medicine describes a new Dual CAR T cell immunotherapy that can help fight HIV infection.

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BCG Vaccine Does Not Protect Against COVID-19, Data Suggests
News   Sep 22, 2020

Using information from the Swedish public health agency, researchers determined that BCG vaccination during infancy actually does not protect against the SARS-CoV-2 virus.

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CD19 in Brain Cells May Be Cause of Immunotherapy-Related Neurotoxicity
News   Sep 22, 2020

New research has uncovered the presence of CD19 -- a B cell molecule targeted by chimeric antigen receptor (CAR) T cell immunotherapy to treat leukemia, lymphoma, and multiple myeloma -- in brain cells that protect the blood brain barrier (BBB).

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Children’s Immune Response Protects Them Against COVID-19 According to New Study
News   Sep 22, 2020

A new study compares the immune responses of adults and children with COVID-19. The study findings detected key differences that may contribute to understanding why children usually have milder disease than adults.

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Well-Known Biomarker for Neurodegenerative Disease Detectable in the Eye
News   Sep 22, 2020

A new study led by Boston Medical Center researchers indicates a well-known biomarker that serves as a marker for earlier diagnosis of neurodegenerative diseases is now detectable in the eye.

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Insights Into Therapeutic Mechanisms of Cancer Drug Pomalidomide
News   Sep 22, 2020

Researchers report novel findings concerning the therapeutic mechanisms of pomalidomide. They showed that pomalidomide causes the breakdown of a protein called ARID2. ARID2 promotes the "expression" of genes that are critical for the growth of multiple myeloma cells, so breaking down ARID2 is harmful to the cancer cells and beneficial to patients.

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How the Loss of a Single Protein Leads to a Relentless Neuromuscular Disease
News   Sep 21, 2020

A new study has laid out the steps that connect the neuromuscular disorder spinal muscular atrophy (SMA) to the mutations in the gene SMN1 that cause the condition. The research may explain how the mutations affect motor neurons and points the way to a better understanding of SMA.

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KRAS Inhibitor Sotorasib Achieves Durable Clinical Benefit in Early Trial
News   Sep 21, 2020

In a Phase I clinical trial for patients with advanced solid cancers marked by KRAS G12C mutations, the KRASG12C inhibitor sotorasib (AMG 510) resulted in manageable toxicities and durable clinical benefit.

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