Ablynx and Merck Serono Further Strengthen their Collaboration
News Oct 02, 2013
Ablynx and Merck Serono announced that they have further expanded their relationship through a multi-year research alliance that could lead to at least four co-discovery and co-development collaborations.
Under the terms of the agreement, Merck Serono will fund a dedicated discovery group at Ablynx. Both partners will jointly select disease targets against which this group will develop Nanobodies, up to in vivo proof-of-principle. The dedicated group will focus on the discovery and development of Nanobodies against a number of targets across multiple disease areas. The collaboration will span all of Merck Serono’s core research and development fields, including oncology, immuno-oncology, immunology and neurology.
Dr Edwin Moses, Chairman and CEO of Ablynx commented: “This is a very exciting expansion of our partnership with Merck Serono, building on the success of our existing collaborations and allowing us to exploit the broad and powerful applicability of our Nanobody platform with a partner with whom we have successfully worked for over five years. The new alliance is an early stage discovery initiative, which allows the companies to rapidly explore the potential of novel targets across a range of therapeutic areas and to determine which programmes should be prioritised for later stage development. It is a very interesting model that could create substantial value for both parties and one which we believe could be applicable for us in other partnerships.”
“We have established a very trustful and productive partnership with Ablynx and a first compound has entered Phase I at the beginning of 2013,” added Dr Bernhard Kirschbaum, Executive Vice President, Head of Global Research and Early Development at Merck Serono and Member of the Merck Serono Executive Board. “Through our extensive collaboration history with Ablynx, both sides know how to best conceptually design programmes to ensure technology fit, differentiation potential and a clear scientific rationale. Our common goal is to develop novel biologics with a high degree of differentiation for high-value therapeutic targets.”
The research alliance will have a term of four years, with the option to extend by two and a half years. Research funding from Merck Serono over the first four years will be over €25 million, including an initial payment of €11.5 million at signing, and will aim to ensure that the collaboration could deliver at least six programmes with proof-of-principle in a relevant animal model.
Building Molecular Wires, One Atom at a TimeNews
Electronic devices are getting smaller and smaller. Early computers filled entire rooms. Today you can hold one in the palm of your hand. Now the field of molecular electronics is taking miniaturization to the next level. Researchers are creating electronic components so tiny they can’t be seen with the naked eye.READ MORE
Study Reveals How MRSA Infection Compromises Lymphatic FunctionNews
Infections of the skin or other soft tissues with the hard-to-treat MRSA bacteria appear to permanently compromise the lymphatic system, which is crucial to immune system function. Investigators describe how MRSA infection impairs the ability of lymphatic vessels to pump lymphatic fluid to lymph nodes in mouse models, which may contribute to the frequent recurrences of MRSA infection experienced by patients.
Possible Biomarker to Identify Who Would Benefit from ImmunotherapyNews
While immunotherapy has made a big impact on cancer treatment, the fact remains that only about a quarter of patients respond to these treatments. In a new study, researchers examined tissue samples from melanoma and ovarian cancer patients treated with immunotherapies and found a link between the percentage of antigen-presenting cells expressing PD-L1 and an objective clinical response to treatment.READ MORE