Advance could Speed use of Genetic Material RNA in Nanotechnology
News Jan 19, 2011
Their findings, which could speed the use of RNA nanotechnology for treating disease, appear in the monthly journal ACS Nano.
Peixuan Guo and colleagues point out that DNA, the double-stranded genetic blueprint of life, and RNA, its single-stranded cousin, share common chemical features that can serve as building blocks for making nanostructures and nanodevices. In some ways, RNA even has advantages over DNA. The field of DNA nanotechnology is already well-established, they note. The decade-old field of RNA nanotechnology shows great promise, with potential applications in the treatment of cancer, viral, and genetic diseases. However, the chemical instability of RNA and its tendency to breakdown in the presence of enzymes have slowed progress in the field.
The scientists describe development of a highly stable RNA nanoparticle. They tested its ability to power the nano-sized biological motor of a certain bacteriophage — a virus that infects bacteria — that operates using molecules of RNA. The modified RNA showed excellent biological activity similar, even in the presence of high concentrations of enzymes that normally breakdown RNA. The finding show that “it is practical to produce RNase (an enzyme that degrades RNA) resistant, biologically active, and stable RNA for application in nanotechnology,” the article notes.
The paper, entitled 'Fabrication of Stable and RNase-Resistant RNA Nanoparticles Active in Gearing the Nanomotors for Viral DNA Packaging' can be found online in ACS Nano
Source: ACS Nano
Smart Label Could One Day Let You Know When To Toss FoodNews
Scientists have developed a low-cost, portable, paper-based sensor that can carry out a number of analytical functions with easy-to-read results.READ MORE
FANTOM5 Releases First Integrated Atlas of microRNA Expression in Human Primary CellsNews
Leveraging the collection of RNA samples established as part of the fifth edition of FANTOM, the team has sequenced microRNA libraries of hundreds of human samples, including many cell types for which the microRNA presence had never been investigated before.READ MORE
Test Successfully Identifies Which Research Results in Mice Will Help Humans With MSNews
In determining which genes are conserved across species, the researchers also discovered a new gene that improves myelin repair.READ MORE