Affymetrix and ExonHit Collaborate to Combine Technologies
News Oct 18, 2005
ExonHit Therapeutics has announced a supply and service provider agreement to combine Affymetrix' GeneChip® microarray platform and ExonHit's alternative RNA splicing technologies and expertise.
ExonHit's SpliceArray content and patented probe design help detect all known transcripts including alternative spliced variants.
The GeneChip arrays featuring the ExonHit SpliceArray content are expected to be available on the Affymetrix platform by year end.
These products will include GPCR, Ion Channel, Nuclear Receptor, Apoptosis and the Cytokine gene families, as well as other custom designs.
“We are pleased to offer our technology on the Affymetrix microarray platform,” said Laurent Bracco, Senior VP Technology ExonHit Therapeutics.
“ExonHit is committed to providing the scientific community with microarrays designed to interrogate complete transcriptomes.”
“Not taking into account RNA Splicing would be like only looking at the tip of the genomic iceberg.”
“Affymetrix is a leader in the microarray-based solutions and we will now be able to offer our patent protected SpliceArray products on the industry-leading GeneChip microarray platform.”
A simple license agreement with ExonHit will enable customers to access ExonHit's microarray content.
Customers can then purchase the GeneChip arrays featuring the SpliceArray content directly from Affymetrix.
License fees will be directly proportional to the number of SpliceArrays purchased, with significant discounts for volume commitments and no reach-through rights.
Alternatively, ExonHit, as an Affymetrix Authorized Service Provider, can run and analyze customers' samples through its SpliceArray Service.
During the recent conference, "Splicing 2005" held in Bethesda MD, USA, Alan Williams, Director of Chip Design at Affymetrix presented the recently launched Affymetrix GeneChip Human Exon 1.0 ST Array, which offers whole-genome, exon-level expression profiling on a single array.
“This collaboration with Affymetrix strengthens ExonHit's ability to ensure the rapid penetration of the microarray market with our unique SpliceArray products,” commented Bruno Tocque, CEO of ExonHit Therapeutics.
“We are now working with the two leading companies in this field and this will be of benefit to scientists who will now be able to choose between different platforms to run their SpliceArrays.”
“This deal is in line with our overall business strategy to capitalize on our world leadership position in the field of alternative splicing analysis in the areas of gene profiling, diagnostics and therapeutics in order to enable us generate a clear short and long terms revenues stream,” he added.
Analytical Tool Predicts Disease-Causing GenesNews
Predicting genes that can cause disease due to the production of truncated or altered proteins that take on a new or different function, rather than those that lose their function, is now possible thanks to an international team of researchers that has developed a new analytical tool to effectively and efficiently predict such candidate genes.
Single Gene Change in Gut Bacteria Alters Host MetabolismNews
Scientists have found that deleting a single gene in a particular strain of gut bacteria causes changes in metabolism and reduced weight gain in mice. The research provides an important step towards understanding how the microbiome – the bacteria that live in our body – affects metabolism.READ MORE
Gotta Sample 'Em All! Underwater Pokéball Captures Ocean LifeNews
A new device developed by Wyss Institute reseachers safely traps delicate sea creatures inside a folding polyhedral enclosure and lets them go without harm using a novel, origami-inspired design. The ultimate aim is to allow the sea creatures to be (gently) analyzed in high detail.READ MORE
International Conference on Neurooncology and Neurosurgery
Sep 17 - Sep 18, 2018