Artemis Announces Collaboration Agreement with Bristol-Myers
News Mar 01, 2006
Under the agreement Artemis will generate various genetically-engineered murine models carrying selected genetic mutations.
Bristol-Myers Squibb will use these models in its drug discovery research activities for the validation of drug screening targets.
Such targets are used to identify compounds and therapies for the treatment of diseases for various indications in humans.
The generation of the in vivo rodent models will be based on Artemis' proprietary ArteMice™ and ArteMice™ Conditional™ technologies.
These technologies are designed to enable the introduction of genetic sequences containing the CreER gene switch for conditional gene knock out and the creation of humanized conditional mutants in which murine genes are replaced by their human orthologues.
Quality control and transfer will be done together with Artemis' strategic partner company Taconic, which also provides use licenses to Bristol-Myers Squibb covering the U.S. territory for mouse models generated by Artemis, using techniques included in the PNS and Isogenic DNA patents.
Molecular biologists long thought that domains in the genome’s 3D organization control how genes are expressed. After studying highly rearranged chromosomes in fruit flies, researchers now reveal that while this is the case for some genes, their results challenge the generality of this for many others.READ MORE