Rice University chemist László Kürti and his lab have received a prestigious Maximizing Investigators' Research grant from the National Institutes of Health (NIH) to speed up drug design by simplifying the synthesis of essential precursors.
The five-year grant worth $1.87 million, administered by the National Institute of General Medical Sciences, will support the lab's continuing research into amines and their derivatives. These common, nitrogen-containing structural motifs are present in the overwhelming majority of drug molecules, agrochemicals and functional materials as well as compounds produced by living organisms.
Amines are also valuable as intermediates for the synthesis of new drugs. A simple method to synthesize these building blocks makes them more available for such use, said Kürti, an associate professor of chemistry.
Exposing the amines' nitrogen atoms in their unprotected forms allows them to more easily react with other molecules, he said. The project abstract noted the compounds the lab hopes to produce "could have a far-reaching impact upon how organic synthesis, medicinal chemistry, biochemistry and chemical biology are practiced."
"We're grateful to the NIH for their continued support of our research program," Kürti said. "The important discoveries made and the high-profile papers published since 2015 would not have been possible without the hard work, dedication and innovative spirit of my graduate students and postdoctoral fellows. I am indebted to them and looking forward to many new and exciting discoveries during the next five years."
He also expects the lab's precursors will enable more environmentally friendly drug development.
The Kürti lab specializes in simplifying synthetic processes once seen as difficult, if not impossible. In recent years, the lab has introduced methods to make aziridines that react with other agents, azetidines that serve as scaffolds for pharmaceutical design and a one-step technique to add nitrogen to compounds for drugs, pesticides, fertilizers and other products.
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