Cisbio and Lumiphore Announce Partnership for new Product and Technology Development
News Sep 11, 2007
Under the agreement, Cisbio holds the exclusive rights to apply Lumi4™ technology to current and future research and development initiatives in TR-FRET-based (Time-Resolved Fluorescence Resonance Energy Transfer) assays for drug discovery.
Lumi4™ compounds bring photophysical properties, increased sensitivity and stability to TR-FRET assays for high-throughput screening (HTS) applications and the growing homogeneous assay market.
The incorporation of Lumi4™ compounds to Cisbio’s proprietary HTRF® technology has the potential to enable the development of a second generation of assay platforms used in HTS, particularly in the fields of GPCR (G-Protein Coupled Receptors) and kinase screening.
Combining the two technologies will allow for the development of new HTRF® applications and increased possibilities for HTS implementation of Cisbio’s assays.
Researchers have found that two structurally similar compounds – deguelin and rotenone, naturally occurring pesticides produced by many plant species – interfered with melanoma cancer cells’ metabolism. Further testing with deguelin showed that it inhibited oxygen consumption in the cells’ mitochondria, effectively starving the cells of energy.READ MORE